Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.0K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid hormones maintain parvalbumin neuron functions in the mouse neocortex.

iScience·2026
Same author

A single nucleotide insertion prevents the in vivo response of the Hairless gene to thyroid hormone.

Endocrinology·2026
Same author

A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

SOSHI-seq: a high-throughput screening assay to test the functionality of putative response elements for nuclear hormone receptors.

Scientific reports·2025
Same author

Thyroid Hormones Act as a Timer for the Postnatal Maturation of Parvalbumin Neurons in Mouse Neocortex.

Thyroid : official journal of the American Thyroid Association·2025
Same author

An Atlas of Thyroid Hormone Responsive Genes in Adult Mouse Hypothalamus.

Endocrinology·2025
Same journal

Obesity-related thyroid reflections: from weight gain to weight loss.

European thyroid journal·2026
Same journal

Triiodothyroacetic acid exerts tissue-specific thyromimetic effects without tachycardia and hyperthermia in male mice.

European thyroid journal·2026
Same journal

Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma.

European thyroid journal·2026
Same journal

Estimation of the delay for resumption of breastfeeding after 131-iodine therapy by milk radioactivity measurement.

European thyroid journal·2026
Same journal

Optimizing Frozen Section Sampling for Thyroid Follicular Neoplasms through Intraoperative Ultrasound Guidance.

European thyroid journal·2026
Same journal

The Effect of Iodinated Contrast Media on Thyroid (Dys)function in Children.

European thyroid journal·2026
See all related articles

Related Experiment Video

Updated: Aug 12, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

481

Thyroid hormone as a temporal switch in mouse development.

Juan Ren1, Frédéric Flamant1

  • 1ENS de Lyon, INRAE, CNRS, Institut de Génomique Fonctionnelle de Lyon, Lyon, France.

European Thyroid Journal
|January 30, 2023
PubMed
Summary
This summary is machine-generated.

Thyroid hormones synchronize post-natal mouse development, similar to amphibian metamorphosis. This review examines their role in brain, brown adipose tissue, and heart development.

Keywords:
metamorphosismousepostnatal developmentthyroid hormone

More Related Videos

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

932
An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.6K

Related Experiment Videos

Last Updated: Aug 12, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

481
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

932
An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.6K

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Comparative Physiology

Background:

  • Thyroid hormones are critical regulators of development in vertebrates.
  • Amphibian metamorphosis is a well-established example of thyroid hormone action.
  • The role of thyroid hormones in mammalian post-natal development requires further elucidation.

Purpose of the Study:

  • To review the hypothesis that thyroid hormones synchronize post-natal mammalian development.
  • To explore the analogous functions of thyroid hormones in amphibians and mice.
  • To examine the impact of thyroid hormones on specific mouse tissues, including the brain, brown adipose tissue, and heart.

Main Methods:

  • Literature review of studies on thyroid hormone function in amphibian metamorphosis and mammalian post-natal development.
  • Comparative analysis of molecular and physiological mechanisms.
  • Case studies focusing on brain, brown adipose tissue, and heart development in mice.

Main Results:

  • Thyroid hormones play a conserved role in coordinating developmental timing across vertebrate species.
  • Evidence suggests thyroid hormones regulate critical aspects of post-natal development in mice, mirroring their role in amphibian metamorphosis.
  • Specific examples illustrate thyroid hormone-dependent maturation of the brain, brown adipose tissue, and heart.

Conclusions:

  • The hypothesis that thyroid hormones synchronize post-natal mammalian development is supported by comparative evidence.
  • Thyroid hormones are essential for the coordinated maturation of key organs in mammals, analogous to their role in amphibian metamorphosis.
  • Further research into thyroid hormone signaling pathways in mammals could reveal novel therapeutic targets for developmental disorders.