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Thrsp Gene and the ADHD Predominantly Inattentive Presentation
Raly James Perez Custodio1, Mikyung Kim2,3, Young-Chul Chung4
1Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors─IfADo, Ardeystraße 67, 44139 Dortmund, Germany.
ACS Chemical Neuroscience
|January 30, 2023
Summary
This study explores a potential animal model for attention-deficit/hyperactivity disorder predominantly inattentive presentation (ADHD-PI). The Thrsp gene may serve as a biomarker, with THRSP OE mice offering a valid model for ADHD-PI research.
Area of Science:
- Neuroscience
- Genetics
- Behavioral Science
Background:
- Attention-deficit/hyperactivity disorder (ADHD) presents in three distinct forms: predominantly inattentive (ADHD-PI), predominantly hyperactive-impulsive (ADHD-HI), and combined (ADHD-C).
- These presentations may stem from separate etiologies, necessitating distinct research models.
- Current understanding of ADHD neurobiology is limited, complicating the development of specific animal models.
Purpose of the Study:
- To review and identify a potential animal model for the ADHD-PI presentation.
- To assess the face, predictive, and construct validity of candidate models for ADHD-PI.
- To explore the Thrsp gene as a potential biomarker for ADHD-PI.
Main Methods:
- Review of existing literature on ADHD presentations and animal models.
- Evaluation of Spontaneously Hypertensive Rats (SHR/NCrl) as a model for ADHD-C.
- Identification and assessment of potential models for ADHD-PI, focusing on genetic and behavioral validity.
Main Results:
- Spontaneously Hypertensive Rats (SHR/NCrl) show validity for ADHD-C.
- The Thrsp gene is proposed as a potential biomarker for ADHD-PI.
- Transgenic mice overexpressing Thrsp (THRSP OE mice) demonstrate potential as an animal model for ADHD-PI.
Conclusions:
- THRSP OE mice exhibit acceptable face, predictive, and construct validity for modeling ADHD-PI.
- The Thrsp gene may serve as a crucial biomarker for the inattentive presentation of ADHD.
- Further research utilizing THRSP OE mice can advance understanding of ADHD-PI neurobiology and etiology.
Keywords:
ADHD predominantly inattentive (ADHD-PI) presentationSpot14Thyroid hormone-responsive protein (Thrsp)attention-deficit/hyperactivity disorder (ADHD)neural stem/progenitor cells (NSPCs)More Related Videos
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