Microbubbles for human diagnosis and therapy

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Nanotechnology

Background:

• Microbubbles (MBs) were serendipitously discovered over 50 years ago during ultrasound (US) imaging.
• Initially used as contrast enhancers for US imaging, MBs have evolved significantly.
• Their unique properties allow for diverse designs and applications in medicine.

Purpose of the Study:

• To review the intrinsic properties and design versatility of MBs.
• To explore the dual potential of MBs in imaging and therapy.
• To discuss the future perspectives of MBs and nanobubble technology in conjunction with US advancements.

Main Methods:

• Review of existing literature on microbubble technology and ultrasound imaging.
• Analysis of MB design variations, including shell composition, gas content, and surface modifications.
• Examination of therapeutic strategies utilizing MBs for various diseases.

Main Results:

• MBs offer versatile design possibilities, including targeted agents and drug delivery systems.
• New MB generations enable targeted molecular imaging and advanced US systems.
• MBs combined with US show therapeutic potential in cancer, cardiovascular diseases, and inflammation.

Conclusions:

• MBs are crucial for advanced US imaging and targeted therapies.
• Nanobubble technology represents the next frontier in MB applications.
• The synergy between MBs and US imaging promises significant future advancements in medicine.