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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

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Published on: January 24, 2025

Microbubbles for human diagnosis and therapy.

Louise Fournier¹, Thibault de La Taille¹, Cédric Chauvierre¹

¹Université Paris Cité, Université Sorbonne Paris Nord, LVTS, UMRS 1148 INSERM, F- 75018, Paris, France.

|January 30, 2023

Summary

This summary is machine-generated.

Microbubbles (MBs), initially observed during ultrasound (US) imaging, are now vital contrast agents. This review explores their design versatility, dual imaging/therapy potential, and future applications in nanobubble technology.

Keywords:

Microbubbles Molecular imaging Sonoporation Sonothrombolysis Targeted therapy Ultrasound

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Area of Science:

Biomedical Engineering
Medical Imaging
Nanotechnology

Background:

Microbubbles (MBs) were serendipitously discovered over 50 years ago during ultrasound (US) imaging.
Initially used as contrast enhancers for US imaging, MBs have evolved significantly.
Their unique properties allow for diverse designs and applications in medicine.

Purpose of the Study:

To review the intrinsic properties and design versatility of MBs.
To explore the dual potential of MBs in imaging and therapy.
To discuss the future perspectives of MBs and nanobubble technology in conjunction with US advancements.

Main Methods:

Review of existing literature on microbubble technology and ultrasound imaging.
Analysis of MB design variations, including shell composition, gas content, and surface modifications.
Examination of therapeutic strategies utilizing MBs for various diseases.

Main Results:

MBs offer versatile design possibilities, including targeted agents and drug delivery systems.
New MB generations enable targeted molecular imaging and advanced US systems.
MBs combined with US show therapeutic potential in cancer, cardiovascular diseases, and inflammation.

Conclusions:

MBs are crucial for advanced US imaging and targeted therapies.
Nanobubble technology represents the next frontier in MB applications.
The synergy between MBs and US imaging promises significant future advancements in medicine.