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Evolving interplay between natural products and gut microbiota
Ning-Ning Zhang1, Zheng-Meng Jiang1, Shang-Zhen Li2
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
European Journal of Pharmacology
|January 30, 2023
Summary
Natural products can treat diseases by interacting with gut microbiota. This review explores how these natural compounds and gut microbes influence each other, impacting host health and disease.
Area of Science:
- Microbiology
- Pharmacology
- Natural Products Research
Background:
- Gut microbiota imbalance is linked to various human disorders.
- Natural products offer therapeutic potential with fewer side effects.
- The efficacy of many natural products is influenced by gut microbiota.
Purpose of the Study:
- To review the complex interplay between gut microbiota and host diseases.
- To elucidate the molecular mechanisms underlying the interaction between natural products and gut microbiota.
- To summarize the biotransformation of natural products by gut microbiota and their effects on host health.
Main Methods:
- Literature review focusing on studies of natural products and gut microbiota.
- Analysis of natural product metabolism within the gut environment.
- Examination of how natural products modulate gut microbiota composition and function.
Main Results:
- Natural products undergo biotransformation by gut microbiota, influencing their therapeutic activities.
- Natural products can alter the composition and diversity of the gut microbial community.
- These interactions impact gut barrier function and the production of microbial metabolites.
Conclusions:
- Understanding the gut microbiota-natural product interaction is crucial for deciphering therapeutic mechanisms.
- This interplay offers novel strategies for managing microbiota-associated diseases.
- Further research into these bidirectional relationships can advance personalized medicine.
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