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Postsynaptic NMDA Receptor Expression Is Required for Visual Corticocollicular Projection Refinement in the Mouse

Kristy O Johnson1,2, Leeor Harel1, Jason W Triplett3,2,4,5

  • 1Center for Neuroscience Research, Children's National Research Institute, Washington, DC 20010.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 30, 2023
PubMed
Summary

NMDA receptors are crucial for aligning visual maps in the superior colliculus (SC). This study used a novel mouse model to show that deleting NMDA receptors disrupts cortical input organization, revealing their role in sensory map alignment.

Keywords:
Tal1alignmentmap alignmenttopographic maptopographyvisual

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Area of Science:

  • Neuroscience
  • Developmental Biology

Background:

  • Efficient spatial information processing relies on aligned topographic neuronal maps.
  • The superior colliculus (SC) integrates visual inputs from the retina and visual cortex, requiring map alignment.
  • Molecular mechanisms for this alignment process remain largely unknown.

Purpose of the Study:

  • To investigate the role of NMDA receptors in the alignment of visual maps in the SC.
  • To elucidate the molecular mechanisms underlying activity-dependent visual map alignment.

Main Methods:

  • Utilized a novel tamoxifen-inducible Cre-lox conditional genetic knockout mouse line (Tal1-CreERT2).
  • Targeted deletion of the NMDA receptor GluN1 subunit in superficial SC layers (SC-cKO mice) during map alignment.
  • Analyzed L5-V1 axon terminal organization and retinocollicular topography in SC-cKO mice.

Main Results:

  • Conditional deletion of NMDA receptors significantly disrupted L5-V1 axon terminal organization in the SC.
  • Retinocollicular topography remained unaffected, indicating specific disruption of cortical input alignment.
  • Time-course experiments suggest NMDA receptors are vital for refining L5-V1 inputs.

Conclusions:

  • NMDA receptors are critical mediators of activity-dependent visual map alignment in the SC.
  • These findings provide mechanistic insight into how neuronal activity shapes sensory map development.
  • The study introduces a valuable tool for studying SC development and function.