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Antipsychotic-Induced Alterations in Lipid Turnover
Sandra Pereira1,2, Emily Au1,3, Sri Mahavir Agarwal1,4,5
1Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Endocrinology
|January 31, 2023
Summary
Antipsychotics treat schizophrenia but raise metabolic disorder risks. This review explores how these drugs alter lipid metabolism, impacting cardiovascular health.
Area of Science:
- Psychiatry and Pharmacology
- Metabolic Disorders
- Cardiovascular Disease
Background:
- Schizophrenia treatment involves antipsychotics, which carry risks of metabolic disorders and premature cardiovascular death.
- Antipsychotic-induced lipid metabolism alterations are linked to metabolic and cardiovascular diseases.
- Some antipsychotic side effects on lipids are independent of weight gain.
Approach:
- This review synthesizes current knowledge on antipsychotic effects on lipid metabolism.
- It examines modulation at whole-body, tissue, and cellular levels.
- Gaps in understanding intracellular mechanisms are highlighted.
Key Points:
- Antipsychotics significantly impact lipid turnover.
- Metabolic and cardiovascular risks are associated with these drug-induced changes.
- Effects on lipid metabolism can occur independently of weight gain.
Conclusions:
- Further research is needed on the intracellular mechanisms of antipsychotic-induced lipid metabolism changes.
- Understanding these mechanisms is crucial for mitigating adverse metabolic and cardiovascular effects.
- This review provides a comprehensive overview of current knowledge and future research directions.
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