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Updated: Aug 12, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Association between omentin and obstructive sleep apnea: A meta-analysis.

Ningning She1, Na Liu1, Xiaoyong Ren1

  • 1Department of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

The Clinical Respiratory Journal
|January 31, 2023
PubMed
Summary

This meta-analysis reveals lower omentin levels in patients with obstructive sleep apnea (OSA). These findings suggest omentin may serve as a potential diagnostic and therapeutic target for OSA.

Keywords:
adipokinemeta-analysisobstructive sleep apneaomentin

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Area of Science:

  • Endocrinology and Metabolism
  • Sleep Medicine
  • Cardiovascular Research

Background:

  • Obstructive sleep apnea (OSA) is linked to multisystem damage, with complex pathogenesis involving obesity.
  • Adipokines, secreted by adipose tissue, are implicated in OSA, but the role of omentin remains debated.
  • This study investigates omentin's role in OSA, exploring its potential as a diagnostic and therapeutic target.

Approach:

  • A systematic literature search was conducted across multiple databases (PubMed, Embase, Web of Science, etc.) up to May 2022.
  • Eight eligible studies involving 914 participants were included in the meta-analysis.
  • Data synthesis and quality assessment were performed using RevMan 5.3 and Stata 12.0, with the Newcastle-Ottawa Scale for literature quality.

Key Points:

  • Meta-analysis of eight studies showed significantly lower omentin levels in OSA patients compared to controls (SMD = -1.54, p < 0.001).
  • Subgroup analyses by race, sample source, gender, and disease severity consistently demonstrated lower omentin levels in OSA patients.
  • Sensitivity analysis indicated less stable results, and high heterogeneity was noted, necessitating further research.

Conclusions:

  • Omentin levels are significantly reduced in individuals with obstructive sleep apnea.
  • Omentin emerges as a potential biomarker for the diagnosis and treatment of OSA.
  • High heterogeneity underscores the need for more high-quality, large-scale studies to confirm these findings.