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Updated: Aug 12, 2025
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An evolving perspective on novel modified release drug delivery systems for inhalational therapy
Tanvirul Hye1, Sakib M Moinuddin2,3, Tanoy Sarkar2,3
1Oakland University William Beaumont School of Medicine, 586 Pioneer Dr, 48309, Rochester, MI, USA.
Expert Opinion on Drug Delivery
|January 31, 2023
Summary
Inhaled modified release formulations offer potential for reduced dosing frequency in respiratory diseases. This review explores advanced strategies and challenges for developing effective inhaled drug delivery systems.
Area of Science:
- Pulmonary drug delivery
- Respiratory medicine
- Formulation science
Background:
- Inhaled drugs primarily treat respiratory disorders like asthma, COPD, and pulmonary hypertension.
- Targeted, modified, or controlled release inhalation formulations are crucial for better patient compliance and therapeutic results.
Approach:
- This review examines factors influencing inhalable modified release formulations.
- It covers various strategies: dissolution rate-controlled systems, drug complexes, site-specific delivery, drug-polymer conjugates, matrix systems, lipid particles, nanosystems, and mucociliary clearance bypass.
Key Points:
- Modified release inhaled formulations can decrease dosing frequency by prolonging lung residence time.
- Current commercialization of these advanced drug delivery systems is limited and underdeveloped.
- The review details the state-of-the-art, development avenues, and translational challenges for inhaled controlled release formulations.
Conclusions:
- Developing modified release inhaled formulations requires addressing formulation strategies and overcoming translational hurdles.
- Further research into novel technologies is essential for advancing inhaled drug delivery for respiratory conditions.
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