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Lamotrigine-Induced Acute Pancreatitis.
Emad Elmusa1, Muhammad Waleed Raza1, Ahmad Muneeb1
1Internal Medicine, Hospital Corporation of America (HCA) Florida Orange Park Hospital, Orange Park, USA.
Cureus
|February 1, 2023
Summary
Lamotrigine, used for epilepsy and bipolar disorder, may cause acute pancreatitis. This case report highlights lamotrigine as a potential cause, emphasizing the need to consider it when diagnosing pancreatitis.
Area of Science:
- Gastroenterology and Hepatology
- Pharmacology and Therapeutics
Background:
- Drug-induced pancreatitis is uncommon, necessitating the exclusion of other causes.
- Research primarily consists of case reports, with few drugs definitively linked to pancreatitis.
- Lamotrigine, a medication for epilepsy and bipolar disorder, has a weak association with pancreatitis.
Observation:
- A patient developed acute pancreatitis.
- A thorough investigation excluded common causes like alcohol abuse.
- Lamotrigine was identified as the likely causative agent.
Findings:
- This case report provides evidence for lamotrigine as a cause of acute pancreatitis.
- The diagnosis was confirmed after ruling out other potential etiologies.
Implications:
- Clinicians should consider lamotrigine when evaluating patients with acute pancreatitis.
- Further research is warranted to establish the definitive link between lamotrigine and pancreatitis.
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