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Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.9K

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Related Experiment Video

Updated: Aug 12, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Micro RNA in meniscal ailments: current concepts.

Filippo Migliorini1, Gianluca Vecchio2, Riccardo Giorgino3

  • 1Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.

British Medical Bulletin
|February 1, 2023
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) show promise as biomarkers for meniscal injuries. Further research into synovial fluid miRNAs could improve early diagnosis and treatment strategies for meniscal tears.

Keywords:
meniscusmiRNAtearstherapy diagnosis

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Area of Science:

  • Musculoskeletal conditions
  • Gene silencing
  • Biomarker discovery

Background:

  • MicroRNAs (miRNAs) are short non-coding RNAs involved in posttranscriptional gene silencing.
  • miRNAs are gaining attention for their role in musculoskeletal conditions.
  • The potential of miRNAs in meniscal injury diagnosis and treatment is a recent postulate.

Conclusions:

  • Characterizing miRNA expression in synovial fluid may enhance early diagnosis and management of meniscal tears.
  • miRNAs represent a promising area for future research in meniscal injury.
  • Further investigation is needed to resolve controversies and establish clinical applications of miRNAs in meniscal conditions.