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Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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In-situ Hybridization02:31

In-situ Hybridization

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

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Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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Responsive Probes and Molecular Bioimaging.

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  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, QLD 4072, Australia.

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Summary
This summary is machine-generated.

This collection showcases advancements in molecular probes, chemosensors, and nanosensors for molecular recognition, sensing, and imaging applications. It outlines the current state-of-the-art and future directions in this rapidly evolving scientific field.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Focuses on the latest developments in molecular probes, chemosensors, and nanosensors.
  • Highlights applications in molecular recognition, sensing, and advanced imaging techniques.

Discussion:

  • Explores the integration of molecular probes and nanosensors for enhanced detection.
  • Discusses the role of chemosensors in real-time biological and environmental monitoring.

Key Insights:

  • Summarizes cutting-edge research presented in the special collection.
  • Provides an overview of the current progress and challenges in sensor technology.

Outlook:

  • Projects future trends in molecular probe and sensor development.
  • Suggests new avenues for applications in diagnostics and theranostics.