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Related Experiment Video

Updated: Aug 12, 2025

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

Continuously perfusable, customisable, and matrix-free vasculature on a chip platform.

Francois Chesnais¹, Jordan Joel², Jonas Hue³

¹Academic Centre of Reconstructive Science, Centre for Oral, Clinical and Translational Sciences, Faculty of Dentistry Oral & Craniofacial Sciences, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK. francois.chesnais@kcl.ac.uk.

|February 1, 2023

Summary

Researchers developed a new 3D printing method to create vascularised organ-on-chip (VoC) systems. This cost-effective platform enables the growth of perfusable microtissues for regenerative medicine applications.

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Related Experiment Videos

Last Updated: Aug 12, 2025

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

Area of Science:

Tissue Engineering
Regenerative Medicine
Biomaterials

Background:

Creating vascularised cellular environments in vitro is a significant challenge in tissue engineering.
This limitation hinders the development of functional stem cell-derived microtissues for regenerative medicine and research.

Purpose of the Study:

To develop an efficient, rapid, and inexpensive workflow for manufacturing vasculature on chip (VoC) systems.
To create a scalable and customizable platform for growing vascularised and perfusable microtissues in vitro.

Main Methods:

Utilized 3D printing for rapid prototyping of VoC systems.
Integrated a refined organotypic culture system (OVAA) with tissue-specific cells to grow patent capillaries.
Designed a pocket-size flow driver to establish physiological perfusive flow with minimal medium usage.

Main Results:

Successfully created vascularised microtissues using the VoC-OVAA platform.
Maintained perfusion at physiological flow rates for over two weeks, observing flow-dependent vascular remodeling.
Demonstrated a scalable and customizable system for in vitro microtissue vascularization.

Conclusions:

The developed platform offers a novel solution for creating vascularised and perfusable microtissues in vitro.
This technology facilitates the fast prototyping and validation of biomimetic in vitro systems, including multi-tissue constructs.
Enables advancements in regenerative medicine and in vitro disease modeling.