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Stimuli-responsive plasmonic core-satellite hybrid nanostructures with tunable nanogaps
Eun Young Hwang1, Jae Hee Lee1, Min Jeong Kang1
1Department of Bionano Engineering and Department of Bionanotechnology, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Republic of Korea. dlim@hanyang.ac.kr.
Journal of Materials Chemistry. B
|February 1, 2023
Summary
Stimuli-responsive block copolymers create tunable plasmonic nanostructures for enhanced Raman scattering (SERS) nanotags. These hybrid nanostructures show promise for sensitive biosensing applications.
Area of Science:
- Materials Science
- Nanotechnology
- Chemistry
Background:
- Stimuli-responsive block copolymers offer tunable plasmonic properties when integrated with metallic nanoparticles (MNPs).
- Hierarchical metallic nanoparticle hybrids are of significant interest for advanced sensing applications.
Purpose of the Study:
- To develop thermo-responsive plasmonic core-satellite hybrid nanostructures with tunable nanogaps.
- To utilize these nanostructures as surface-enhanced Raman scattering (SERS) nanotags for biosensing.
Main Methods:
- Synthesis of two diblock copolymers: p(AAc-b-NIPAM) (negatively charged) and p(DMAEMA-b-NIPAM) (positively charged).
- Conjugation of copolymers to gold nanospheres (GNSs) and gold nanorods (GNRs) respectively.
- Formation of core-satellite nanostructures via electrostatic complexation and temperature-triggered tuning of nanogaps.
Main Results:
- Successfully synthesized thermo-responsive block copolymers and formed core-satellite hybrid nanostructures.
- Demonstrated dynamic tuning of nanogap electromagnetic coupling through temperature-induced conformational changes.
- Validated the potential of these nanostructures as SERS nanotags in a sandwich-type immunoassay for immunoglobulin G detection.
Conclusions:
- The developed plasmonic core-satellites exhibit stimuli-responsiveness, enabling tunable nanogaps.
- These hybrid nanostructures are promising for advanced SERS-based biosensing applications.
