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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Related Experiment Video

Updated: Jun 16, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

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Recent strategies to develop pH-sensitive injectable hydrogels.

Thavasyappan Thambi1, Jae Min Jung1, Doo Sung Lee1

  • 1School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. dslee@skku.edu.

Biomaterials Science
|February 1, 2023
PubMed
Summary
This summary is machine-generated.

Injectable pH-responsive biomaterials offer precise drug delivery for personalized medicine. These smart hydrogels form depots that control the release of therapeutics, enhancing efficacy and minimizing side effects.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Personalized Medicine

Background:

  • "Smart" biomaterials offer targeted delivery for personalized medications.
  • Injectable pH-responsive biomaterials transition from sol-to-gel, enabling controlled release.
  • These hydrogels can deliver chemotherapeutics, peptides, and proteins minimally invasively.

Purpose of the Study:

  • To review advances in biodegradable, in situ-forming injectable pH-responsive biomaterials.
  • To highlight the development and application of amphoteric pH-responsive biomaterials.
  • To discuss challenges and future directions for clinical translation.

Main Methods:

  • Review of literature on pH-responsive biomaterials.
  • Focus on hydrogel properties like biodegradability and drug interaction.
  • Analysis of in situ gelation and controlled release mechanisms.

Main Results:

  • Injectable pH-responsive hydrogels provide controlled release of bioactive agents.
  • Tunable properties allow for precise control over drug release kinetics.
  • Amphoteric pH-responsive biomaterials show promise in biomedical applications.

Conclusions:

  • Biodegradable, injectable pH-responsive hydrogels are promising for targeted therapy.
  • Further research is needed to address challenges in clinical translation.
  • These smart biomaterials hold potential for enhanced therapeutic outcomes.