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Topical ibuprofen decreases early postburn edema.
1Longwood Area Trauma Center at Brigham and Women's Hospital, Boston, Mass. 02115.
Surgery
|November 1, 1987
Summary
Topical ibuprofen significantly reduced burn edema and prostanoid production in sheep. This study shows ibuprofen cream effectively treats burn inflammation locally without systemic effects.
Area of Science:
- Pharmacology
- Wound Healing
- Burn Research
Background:
- Second-degree burns cause significant edema and inflammation.
- Prostanoids are implicated as causative factors in burn edema.
- Topical anti-inflammatory agents may mitigate burn-induced responses.
Purpose of the Study:
- To evaluate the efficacy of topically applied ibuprofen on burn edema.
- To assess the impact of topical ibuprofen on prostanoid production in burn tissue.
- To determine if topical ibuprofen affects systemic prostanoid levels.
Main Methods:
- Second-degree burns were induced in adult sheep.
- Lymph (QL) and tissue biopsies were collected to measure edema and prostanoids.
- A 5% ibuprofen cream was applied topically at 2 and 5 hours post-burn.
Main Results:
- Topical ibuprofen reduced lymph output (edema) by 58% compared to untreated burns.
- Ibuprofen significantly decreased lymph prostanoid levels (TxB2 and 6-keto-PGF1 alpha).
- Burned hide water content was significantly lower in ibuprofen-treated areas.
Conclusions:
- Topical ibuprofen effectively reduces local edema formation in second-degree burns.
- Ibuprofen application decreases local prostanoid production in burn tissue.
- Systemic prostanoid levels were not significantly altered by topical ibuprofen treatment.