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PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid

Guang-Cong Zhang1, Xiang-Nan Yu1, Hong-Ying Guo1

  • 1Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.

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Pre-mRNA processing factor 19 (PRP19) drives esophageal squamous cell carcinoma (ESCC) growth by altering lipid metabolism. Targeting PRP19 offers a new therapeutic strategy for ESCC patients.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Lipid metabolism reprogramming is a key feature of cancer cells.
  • Understanding metabolic regulators in esophageal squamous cell carcinoma (ESCC) is crucial for developing new therapies.

Purpose of the Study:

  • To investigate the role of pre-mRNA processing factor 19 (PRP19) in regulating lipid metabolism in ESCC.
  • To determine if PRP19 can serve as a therapeutic target for ESCC.

Main Methods:

  • Analyzed PRP19 expression in ESCC patient cohorts.
  • Assessed the impact of PRP19 on ESCC cell proliferation in vitro and in vivo.
  • Investigated the mechanism by which PRP19 influences fatty acid synthesis via sterol regulatory element-binding protein 1 (SREBF1).
  • Examined the role of N6-methyladenosine in PRP19-mediated SREBF1 mRNA stabilization.

Main Results:

  • PRP19 expression was significantly elevated in ESCC and associated with poor prognosis.
  • PRP19 overexpression promoted ESCC cell proliferation.
  • PRP19 upregulated fatty acid synthesis by enhancing SREBF1 activity.
  • PRP19 stabilized SREBF1 mRNA through an N6-methyladenosine-dependent pathway.

Conclusions:

  • PRP19 plays a critical role in reprogramming fatty acid metabolism in ESCC.
  • PRP19 is a potential prognostic biomarker and therapeutic target for ESCC.
  • Targeting PRP19 may reverse metabolic reprogramming and inhibit ESCC progression.