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Metabolic dialogs between B cells and the tumor microenvironment: Implications for anticancer immunity.
Su Jiang1, Ranran Feng1, Ziying Tian1
1Department of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cancer Letters
|February 1, 2023
Summary
B cells play a crucial role in cancer immunotherapy outcomes. This review explores how B cell metabolism within the tumor microenvironment impacts anti-cancer immunity, highlighting key challenges and future research directions.
Area of Science:
- Immunometabolism
- Cancer Immunology
- B cell biology
Background:
- B cells and tertiary lymph structures correlate with positive outcomes in cancer immunotherapy.
- The tumor microenvironment presents metabolic challenges to effective anti-tumor B cell responses.
- Certain metabolites produced by B cells can suppress anti-cancer immunity.
Purpose of the Study:
- To review key studies on B cell immunometabolism in cancer.
- To summarize the metabolic life of B cells within the tumor context.
- To identify critical questions for future research in B cell immunometabolism and anti-tumor immunity.
Main Methods:
- Literature review of immunometabolism studies focusing on B cells in cancer.
- Analysis of intrinsic metabolic pathways of B cells.
- Discussion of metabolic interactions between tumor microenvironment and tumor-infiltrating B cells.
Main Results:
- B cell metabolic state is significantly influenced by the tumor microenvironment.
- Tumor-associated B cells exhibit distinct metabolic profiles.
- B cell-derived metabolites can have dual roles, potentially inhibiting anti-tumor responses.
Conclusions:
- Understanding B cell immunometabolism is vital for enhancing cancer immunotherapy efficacy.
- Metabolic crosstalk between B cells and the tumor microenvironment is a critical determinant of anti-tumor immunity.
- Further research into B cell metabolic pathways and their products is needed to develop novel therapeutic strategies.
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