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Metabolic dialogs between B cells and the tumor microenvironment: Implications for anticancer immunity

Su Jiang1, Ranran Feng1, Ziying Tian1

  • 1Department of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Cancer Letters
|February 1, 2023
PubMed

Immunometabolism, a branch of biology describing the link between immunity and metabolism, is an emerging topic in cancer immunology. It is currently well accepted that B cells and tertiary lymph structures formed by them are associated with favorable outcomes when patients undergo cancer immunotherapy. Understanding the determinants of B-cell fate and function in cancer patients is necessary for improving cancer immunotherapy. Accumulating evidence points to the tumor microenvironment being a critical metabolic hurdle to an efficient antitumor B-cell response. At the same time, several B-cell-derived metabolites have recently been reported to inhibit anticancer immunity. In this literature review, key B-cell immunometabolism studies and the metabolic life of B cells were summarized. Then, we discussed the intrinsic metabolic pathways of B cells themselves and how the tumor microenvironment and B cells in tumors metabolically influence each other. Finally, we pointed out key questions to provide some inspiration for further study of the role of B-cell immunometabolism in the antitumor immune response.

Keywords:
Anticancer immunityB-Cell differentiationB-Cell-derived metabolitesGlycolysisImmunometabolism

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