Related Experiment Video
Updated: Aug 12, 2025

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
Published on: September 25, 2009
[A case of caseous calcification of mitral annulus resulting in multiple cerebral infarctions]
Yoshifumi Ogasawara1, Kagari Mano1,2, Fumiaki Henmi1
1Department of Neurology, Toranomon Hospital.
Insights
A rare case of stroke caused by a mobile mitral valve mass (caseous calcification of the mitral annulus) highlights the importance of cardiac evaluation for embolic events.
Area of Science:
- Cardiology
- Neurology
- Cardiovascular Surgery
Background:
- Mitral annular calcification (MAC) is common in the elderly.
- Caseous calcification of the mitral annulus (CCMA) is a rare subtype of MAC.
- CCMA can present as a mobile mass with embolic potential.
Observation:
- A 73-year-old woman presented with acute cerebral infarctions.
- Echocardiography revealed a large, mobile CCMA on the mitral valve annulus.
- A new infarction occurred, indicating embolic events from the CCMA.
Findings:
- The CCMA was resected, and mitral valve replacement was performed.
- This case represents a rare instance of embolic cerebral infarction caused by CCMA.
- CCMA can progress to a calcified amorphous tumor (CAT) with embolic risks.
Implications:
- Early detection and surgical intervention for CCMA are crucial in preventing recurrent embolic events.
- This case underscores the need for comprehensive cardiac assessment in patients with cryptogenic stroke.
- Understanding CCMA as a source of embolism can improve stroke management strategies.
Abstract:
The patient is a 73-year-old woman. She presented with dysarthria, and a head MRI revealed multiple acute cerebral infarctions in the bilateral cerebral hemisphere and cerebellar hemisphere. Transesophageal echocardiography after admission revealed a 16 mm large mobile calcification of the mitral annulus (caseous calcification of the mitral annulus; CCMA) on the posterior apex of the mitral valve annulus. Since the CCMA had a high risk of relapse, and a new infarction was detected on the 8th day, resection of the mass and mitral valve replacement surgery were performed. CCMA is a subtype of mitral annular calcification (MAC). When calcification progresses from the MAC state to form a mass, it is called a calcified amorphous tumor; CAT. Reports of embolic cerebral infarction caused by CAT are rare, but this is a rare report of an embolic cerebral infarction from CCMA presenting as CAT.
Related Concept Videos
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis I: Introduction
Mitral Regurgitation I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Valve Prolapse I: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies

