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Clinical Metagenomics for Infectious Diseases: Progress toward Operational Value
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Journal of Clinical Microbiology
|February 2, 2023
Summary
Clinical metagenomics for infectious diseases needs standardized methods. A new "operational value" concept assesses result quality, utility, and cost to advance diagnostic accuracy and patient care.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Clinical metagenomics for infectious disease diagnostics is rapidly advancing.
- Lowering implementation barriers necessitate addressing technical methodologies and best-use practices.
- Challenges exist in standardizing diverse clinical metagenomic approaches.
Purpose of the Study:
- To identify challenges in clinical metagenomics development.
- To propose methods for advancing the field, including a novel "operational value" concept.
- To highlight a pilot study on targeted metagenomics for infectious endocarditis.
Main Methods:
- The commentary introduces "operational value" for standardizing clinical metagenomic results.
- Operational value assesses result quality, utility, and cost.
- An operational value matrix is proposed for standardizing outcome-based metrics.
Main Results:
- The commentary identifies key challenges in clinical metagenomics.
- It proposes operational value as a standardization method.
- A pilot study on targeted metagenomics for infectious endocarditis is highlighted.
Conclusions:
- Standardizing clinical metagenomic approaches is crucial for reliable infectious disease diagnostics.
- Operational value offers a framework for assessing and comparing different metagenomic methods.
- New study designs and collaborations are needed to integrate clinical metagenomics into routine patient care.
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