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Multisystem Inflammatory Syndrome in American Indian/Alaska Native Children, March 2020-May 2022

Ethan R Bornstein1,2,3, Allison D Miller1, Laura D Zambrano1

  • 1From the CDC COVID-19 Response Team.

The Pediatric Infectious Disease Journal
|February 2, 2023
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) disproportionately affected younger, obese American Indian and Alaska Native (AI/AN) youth, particularly those from vulnerable areas. AI/AN children experienced more severe respiratory issues and shock.

Area of Science:

  • Pediatric infectious diseases
  • Epidemiology
  • Health disparities

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition following viral infections.
  • Understanding ethnic and geographic disparities in MIS-C is crucial for targeted public health interventions.

Purpose of the Study:

  • To compare the characteristics, clinical features, and outcomes of MIS-C in American Indian and Alaska Native (AI/AN) children versus non-Hispanic white children.
  • To identify risk factors and disparities associated with MIS-C in AI/AN populations.

Main Methods:

  • Retrospective cohort study comparing AI/AN and non-Hispanic white pediatric patients diagnosed with MIS-C.
  • Analysis of demographic data, clinical presentations, disease severity, and outcomes.

Main Results:

  • AI/AN MIS-C patients were younger and had higher rates of obesity compared to non-Hispanic white patients.
  • AI/AN patients originated from areas with greater social vulnerability.
  • A higher proportion of AI/AN patients presented with severe respiratory involvement and shock.

Conclusions:

  • Significant disparities exist in MIS-C presentation and severity among AI/AN children.
  • Younger age, obesity, social vulnerability, and severe clinical manifestations highlight specific risks for AI/AN youth with MIS-C.

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