Related Experiment Video
Updated: Aug 12, 2025
07:08
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
10.1K
Artificial intelligence in glaucoma: posterior segment optical coherence tomography.
Alfredo Gutierrez1,2, Teresa C Chen2,3
1Tufts School of Medicine.
Current Opinion in Ophthalmology
|February 2, 2023
Summary
Deep learning (DL) models show high accuracy in detecting glaucoma using optical coherence tomography (OCT) scans. While promising for glaucoma management, no DL tools are yet FDA-approved for diagnosis due to varied OCT definitions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Artificial Intelligence
Background:
- Glaucoma detection and surveillance rely heavily on optical coherence tomography (OCT) imaging.
- Deep learning (DL) presents a novel approach to analyze complex OCT data for diagnosing glaucomatous optic neuropathy (GON).
Approach:
- This review summarizes recent literature on DL model applications for glaucoma detection and surveillance using posterior segment OCT.
- DL models utilize OCT-derived parameters such as retinal nerve fiber layer (RNFL), macular scans, and optic nerve head (ONH) scans, often in combination.
Key Points:
- DL models achieve high diagnostic accuracy for GON, frequently employing combined OCT parameters for a comprehensive analysis.
- While RNFL segmentation is common, DL models increasingly integrate multiple OCT parameters.
- DL models for predicting glaucoma progression are less studied but are under development.
Conclusions:
- DL models offer efficient and objective tools for glaucoma management.
- Despite AI's commercial success in other ophthalmic diseases, a DL tool for glaucoma diagnosis lacks FDA approval, potentially due to the absence of a universal OCT-based definition of glaucoma.
Related Concept Videos
01:25Glaucoma: Overview
674
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
674
01:27Open Angle Glaucoma: Treatment
516
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
516
01:28Angle Closure Glaucoma: Treatment
604
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
604