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PATTERNS OF SUBRETINAL AND/OR INTRARETINAL FLUID RECURRENCE IN PATIENTS WHO RECEIVED AS-NEEDED RANIBIZUMAB THERAPY IN
Sean D Adrean1, Siyang Chaili1,2, Lauren Hill3
1Retina Consultants of Orange County, Fullerton, California.
Retina (Philadelphia, Pa.)
|February 2, 2023
Summary
Recurrent fluid in age-related macular degeneration (AMD) most often appears centrally, even if initially elsewhere. Some patients experience new fluid locations, suggesting potential new disease activity.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Age-Related Macular Degeneration
Background:
- Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss.
- Subretinal fluid (SRF) and intraretinal fluid (IRF) are key indicators of disease activity in nAMD.
- As-needed (PRN) ranibizumab is a common treatment for nAMD, but fluid recurrence patterns require further investigation.
Purpose of the Study:
- To analyze the recurrence patterns of subretinal fluid and/or intraretinal fluid in patients with nAMD treated with PRN ranibizumab.
- To compare the location of fluid at baseline with the location of recurrence after a period of resolution.
Main Methods:
- A post hoc analysis of the HARBOR trial (NCT00891735) was performed.
- Included patients (N=222) with SRF and/or IRF at baseline and recurrence after ≥3 months of absence.
- Compared baseline fluid locations with recurrence locations.
Main Results:
- Recurrent fluid was most frequently located centrally (69%), unlike baseline fluid distribution.
- Eyes with baseline central fluid typically recurred centrally (72%).
- 37% of eyes showed recurrence in a new location, often centrally (53%), with a mean visual acuity gain of +2.2 letters upon recurrence.
Conclusions:
- Recurrent fluid in nAMD predominantly occurs centrally, regardless of initial location.
- Fluid recurrence in a new location may indicate new choroidal neovascularization.
- Understanding recurrence patterns aids in optimizing nAMD management.
