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[Subchronic toxicity of apramycin in pigs]
Veterinarno-Meditsinski Nauki
|January 1, 1987
Summary
Apramycin sulfate, an antibiotic, was tested for toxicity in pigs. Results indicate it stimulates growth and improves feed conversion without significant adverse effects at recommended doses.
Area of Science:
- Veterinary Pharmacology
- Animal Nutrition
- Toxicology
Background:
- Apramycin sulfate is an antibiotic used in animal husbandry.
- Assessing the toxicity and efficacy of apramycin sulfate is crucial for safe and productive livestock management.
Purpose of the Study:
- To evaluate the toxicity of apramycin sulfate in pigs at various concentrations.
- To determine the effects of apramycin sulfate on animal growth, feed conversion, and clinical-laboratory parameters.
Main Methods:
- Four groups of six pigs (40-50 kg) were administered apramycin sulfate in drinking water at 0, 300, 500, and 1,000 mg/L for 35 days.
- General status, growth, feed conversion, clinico-laboratory indices, and visceral tissues were monitored.
Main Results:
- Apramycin sulfate did not negatively impact the general status of pigs.
- Growth was stimulated and feed conversion improved across tested groups.
- Low concentrations (up to 300 mg/L) showed no significant toxic effects.
- Higher concentrations (500-1,000 mg/L) for over 15 days occasionally caused minor blood count changes and negligible dystrophic changes in liver, kidneys, and heart.
Conclusions:
- Apramycin sulfate demonstrates growth-promoting and feed-efficiency benefits in pigs.
- Toxicity is minimal at recommended levels, with slight hematological and visceral alterations possible at high doses or prolonged administration.