Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune checkpoint inhibitor neurotoxicity: long-term outcomes with focus on 1-year neurological sequelae.

Journal for immunotherapy of cancer·2026
Same author

Isolated Peripheral Nervous System Presentation in Ma/Ma2-Associated Autoimmunity.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Vascular and mesenchymal signatures of breast cancers associated with Yo and Ri paraneoplastic syndrome.

Breast cancer research : BCR·2026
Same author

Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.

International journal of oral science·2026
Same author

Molecular sleuthing: unmasking hidden lymphomas through plasma DNA sequencing.

Journal of medical genetics·2026
Same author

Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study.

The Journal of frailty & aging·2026

Related Experiment Video

Updated: Aug 12, 2025

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.1K

A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model.

Fabrice Faure1, Lidia Yshii2,3,4,5, Toufic Renno6

  • 1Synaptopathies and Autoantibodies (SynatAc) Team, Institut NeuroMyoGène (INMG)-MeLis, INSERM U1314, CNRS UMR 5284, Université de Lyon, Université Claude Bernard Lyon 1, 69373, Lyon, France.

Cerebellum (London, England)
|February 2, 2023
PubMed
Summary
This summary is machine-generated.

This study modeled paraneoplastic cerebellar degeneration using mice, but failed to induce significant Purkinje cell death or motor deficits despite generating anti-Yo antibodies. Further research is needed to overcome model limitations for studying neuroinflammation.

Keywords:
Anti-Yo autoantibodiesAutoantibodiesCDR2L proteinImmune checkpoint inhibitorsParaneoplastic cerebellar degeneration

More Related Videos

Mouse Models of Periventricular Leukomalacia
06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

30.0K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.0K

Related Experiment Videos

Last Updated: Aug 12, 2025

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.1K
Mouse Models of Periventricular Leukomalacia
06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

30.0K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.0K

Area of Science:

  • Neuroscience
  • Immunology
  • Oncology

Background:

  • Paraneoplastic neurological diseases (PNDs) pose challenges due to patient rarity and limited autopsy access.
  • Modeling PNDs is crucial for understanding immune-mediated neuronal death.

Purpose of the Study:

  • To establish a mouse model for paraneoplastic cerebellar degeneration associated with Yo autoantibodies (Yo-PCD).
  • To investigate immune mechanisms contributing to neuronal damage in Yo-PCD.

Main Methods:

  • Mice were implanted with ovarian carcinoma cells expressing CDR2/CDR2L antigens.
  • Immunization with antigens, adjuvants, and immune checkpoint inhibitors was performed.
  • Assessment included motor function, autoantibody levels, Purkinje cell density, and cerebellar immune infiltration.

Main Results:

  • Anti-Yo antibodies were detected in serum and CSF of immunized mice.
  • Subcutaneous tumor implantation led to significant immune cell infiltration in the brain.
  • No substantial Purkinje cell loss or motor impairment was observed in any group.

Conclusions:

  • The current mouse model did not fully replicate Yo-PCD, showing limitations in inducing neuroinflammation and neuronal death.
  • Potential factors include the time required for neuroinflammation, tumor antigen presentation, and species-specific immune responses.