Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

332
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
332
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

268
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
268
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

353
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
353
Histology of the Small Intestine01:27

Histology of the Small Intestine

1.3K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
1.3K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

185
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
185

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-Time CustomGPT Generated Feedback for Medical Students: A Simulation-Based Pilot Study.

Academic pediatrics·2026
Same author

Retroperitoneal Schwannoma with a Novel <i>PRCC::TFE3</i> Fusion: Expanding the Spectrum of Schwannomas with a <i>TFE3</i> Gene Rearrangement.

International journal of surgical pathology·2026
Same author

NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition.

Molecular cancer therapeutics·2026
Same author

Evaluating the Impact of Intensive Care Unit Rotations During the Pediatric Clerkship.

Medical science educator·2026
Same author

Leveraging microbiota-metabolites to reduce inflammation and promote functional recovery following spinal cord injury in female mice.

Brain, behavior, & immunity - health·2025
Same author

Clinicopathologic Characterization of Liver Biopsies of Patients with Congenital Hyperinsulinism Presenting with Neonatal Cholestasis.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2025
Same journal

Constipation outcomes in children with and without autism spectrum disorder: Insights from a tertiary motility service.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Heterogeneous outcomes in pediatric potential celiac disease: A multicenter longitudinal study.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Inter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Foreign body ingestions in children and adolescents: A position paper of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) endoscopy special interest group.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.

Journal of pediatric gastroenterology and nutrition·2026
See all related articles

Related Experiment Video

Updated: Aug 12, 2025

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

1.4K

Isolated Terminal Ileitis in Children.

Arik Alper1, Aaron Bennett2, Douglas Rottmann3

  • 1From the Department of Pediatrics, Yale University, New Haven, CT.

Journal of Pediatric Gastroenterology and Nutrition
|February 2, 2023
PubMed
Summary
This summary is machine-generated.

In children, isolated terminal ileitis often progresses to Crohn disease (CD). However, those with idiopathic terminal ileitis showed no CD development over 83 months, indicating a favorable long-term outcome.

More Related Videos

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

9.5K
Catheterization of Intestinal Loops in Ruminants
17:15

Catheterization of Intestinal Loops in Ruminants

Published on: June 11, 2009

13.7K

Related Experiment Videos

Last Updated: Aug 12, 2025

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

1.4K
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

9.5K
Catheterization of Intestinal Loops in Ruminants
17:15

Catheterization of Intestinal Loops in Ruminants

Published on: June 11, 2009

13.7K

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Outcomes

Background:

  • Isolated terminal ileitis is uncommon in children, with limited data on its progression to Crohn disease (CD).
  • Understanding the natural history of pediatric isolated terminal ileitis is crucial for accurate diagnosis and management.
  • Distinguishing between Crohn disease and idiopathic terminal ileitis in children is clinically significant.

Approach:

  • Retrospective chart review of 956 children undergoing colonoscopy (2013-2017).
  • Analysis of clinical, endoscopic, histologic, and radiologic features.
  • Long-term follow-up of children diagnosed with isolated terminal ileitis.

Key Points:

  • Thirty-three children had isolated terminal ileitis; 17 developed CD, and 16 had idiopathic terminal ileitis.
  • Children with CD showed higher C-reactive protein levels, severe inflammation, and bowel wall thickening.
  • Idiopathic terminal ileitis cases did not progress to CD over an 83-month follow-up.

Conclusions:

  • Crohn disease is a common diagnosis in children presenting with isolated terminal ileitis.
  • Children with idiopathic terminal ileitis have a favorable long-term prognosis without progression to Crohn disease.
  • This study highlights key differences between Crohn disease and idiopathic terminal ileitis in pediatric populations.