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Updated: Aug 11, 2025

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
Published on: October 23, 2020
Tahmina Nasrin Poly1, Md Mohaimenul Islam2, Bruno Andreas Walther3
1Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan; International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei 110, Taiwan; Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
This study provides a comprehensive overview of how artificial intelligence is being used to detect and manage diabetic retinopathy. By analyzing nearly a thousand research papers published over the last decade, the authors identify the most influential countries, institutions, and researchers driving this field forward.
Area of Science:
Background:
No prior work had resolved the lack of a systematic scientometric overview regarding the application of machine learning in retinal disease management. While interest in this intersection has grown significantly, the landscape of global research output remained unmapped. Prior research has shown that automated diagnostic tools offer transformative potential for clinical ophthalmology. That uncertainty drove the need for a structured evaluation of existing academic contributions. Scholars have frequently explored individual algorithms, yet a broad synthesis of the entire domain was missing. This gap motivated the current investigation into the evolution of these digital health technologies. Researchers required a clear picture of how international collaboration and institutional focus have shaped the field. Establishing these patterns helps clarify the current state of evidence for practitioners and developers alike.
Purpose Of The Study:
The aim of this study is to provide a systematic overview of the scientific literature concerning artificial intelligence applications in diabetic retinopathy. No prior work had resolved the lack of a comprehensive scientometric report in this specific domain. The authors sought to identify emerging trends and key contributors to the field over the last decade. They intended to map co-authorship networks and institutional productivity to understand the global research landscape. This investigation also explored the specific technological approaches and clinical conditions commonly addressed in recent publications. By analyzing these factors, the researchers hoped to clarify the current state of academic progress. That uncertainty drove the need for a structured evaluation of existing evidence to guide future inquiries. The study ultimately serves to highlight the most influential sources and hot topics for the scientific community.
Main Methods:
Review approach involved a systematic search of the Web of Science database for relevant records. The team screened all retrieved titles to ensure they met the predefined eligibility standards. Only works composed in English were included to maintain consistency throughout the evaluation. The investigators extracted comprehensive bibliographic details from each selected entry for subsequent processing. They employed the Bibliometrix R package to perform a detailed descriptive assessment of the collected data. VOSviewer software facilitated the construction of complex maps representing collaboration networks and institutional links. This methodology allowed for the visualization of annual publication counts and keyword frequency. The researchers synthesized these metrics to identify the most productive authors and journals within the specified timeframe.
Main Results:
Key findings from the literature reveal a total of 931 articles published between 2012 and 2022. The data indicate an increasing trend in annual publication volume throughout this decade. Investigative Ophthalmology and Visual Science emerged as the most frequent source, accounting for 58 of the total papers. IEEE Access followed closely with 54 publications, while Computers in Biology and Medicine contributed 23. China ranked as the most productive country with 211 articles, followed by India with 143 and the USA with 133. The National University of Singapore led institutional output with 40 papers, followed by the Singapore Eye Research Institute at 35. Ting D. was identified as the most productive researcher, having authored 34 of the retrieved studies.
Conclusions:
The authors suggest that the volume of academic output in this domain has experienced a consistent upward trajectory over the last ten years. Synthesis and implications indicate that China, India, and the United States lead global productivity in this specialized area. The findings highlight that specific journals, such as those focusing on visual science and engineering, serve as primary hubs for dissemination. Researchers propose that these bibliometric patterns reflect a maturing field with significant potential for clinical integration. The data suggest that institutional partnerships are becoming increasingly vital for advancing diagnostic accuracy. Future efforts may benefit from focusing on the identified hot topics to address remaining gaps in patient care. The study implies that understanding these publication trends assists stakeholders in navigating the rapidly expanding literature. These results provide a baseline for monitoring how future technological breakthroughs will influence global research priorities.
The researchers propose that the primary mechanism for growth involves increasing international collaboration and institutional investment. This trend is evidenced by the high productivity of leading centers like the National University of Singapore compared to smaller, less active research groups.
The authors utilized the Bibliometrix R package and VOSviewer software to map networks. These tools allow for the visualization of co-authorship patterns and keyword clusters, which are not accessible through standard manual literature reviews.
A technical necessity for the study was the restriction to English-language publications. This criterion ensured that the extracted bibliographic information remained consistent for the descriptive analysis across the 931 collected articles.
The authors extracted bibliographic metadata from the Web of Science database. This data type served as the foundation for constructing the annual publication trends and identifying the most influential journals.
The researchers measured productivity by counting the number of articles per entity. For instance, China produced 211 papers, whereas South Korea contributed 44, illustrating a clear disparity in output volume between these nations.
The authors propose that their findings offer valuable clues for future clinical practice. By identifying hot topics, they suggest that practitioners can better anticipate which diagnostic technologies will likely reach the bedside soon.