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Related Experiment Video

Updated: Aug 11, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

A neural substrate for negative affect dictates female parental behavior.

Salvatore Lecca¹, Mauro Congiu¹, Léa Royon¹

¹The Department of Fundamental Neuroscience, The University of Lausanne, 1005 Lausanne, Switzerland.

|February 2, 2023

Summary

The study reveals that specific neurons in the lateral habenula (LHb) process newborn distress signals in female mice. These neurons are crucial for negative affect and guide maternal care behaviors like pup retrieval.

Keywords:

bed nucleus of the stria terminalis lateral habenula negative affect parental behavior pup retrieval virgin female mice

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Last Updated: Aug 11, 2025

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Area of Science:

Neuroscience
Behavioral Biology
Genetics

Background:

Parental behaviors are vital for offspring well-being and adult emotional regulation.
The neural circuits underlying parental responses to neonatal distress are not fully understood.
Negative affect states can arise when managing neonatal distress becomes difficult.

Purpose of the Study:

To investigate the role of neuronal circuits in orchestrating parental actions in response to neonatal distress.
To identify specific neuronal populations involved in processing distress signals and guiding parental behaviors.
To explore the neurobiological underpinnings of negative affect in the context of parenting.

Main Methods:

Utilized mouse models (virgin females) to study neuronal activity in the lateral habenula (LHb) in response to pup distress vocalizations.
Employed optogenetic and chemogenetic techniques to manipulate and track the activity of bed nucleus of the stria terminalis-innervated LHb (BNSTLHb) neurons.
Conducted intersectional cell identification and transcriptional profiling to characterize BNSTLHb cells and their gene expression patterns.

Main Results:

Identified specific activity patterns in BNSTLHb neurons correlating with pup distress vocalizations and aversive behaviors in virgin female mice.
Demonstrated that BNSTLHb neuronal activity is necessary for pup-call-driven aversive behaviors and pup retrieval.
Found that gene expression in BNSTLHb cells of parenting females resembles that of mothers, distinguishing them from non-parental males.

Conclusions:

A negative affect neural circuit involving BNSTLHb neurons processes newborn distress signals in female mice.
This circuit plays a critical role in guiding female parenting behaviors, particularly pup retrieval.
Understanding these circuits may offer insights into the neurobiology of parental care and negative affect regulation.