[Topological principle in the study of microcirculatory structuro-functional units]

Topological approach, suggested in the work, is a further development of methodology in studying microcirculation, especially its morphological basis. Owing to this approach, it is possible to consider spacial-time (coordinative) interrelations of different transport communications together with their histotopography. Hemato-lymphatic interrelations in the peritoneum can serve as an excellent example. Regularly repeating ansambles of transport communications (vascular and others) are interpreted as systems invariable for structural-functional units of the organ as to transport of fluid in tissues. Such complexes (modules) possess certain anatomy in hemodynamical and metabolic sense. Analysis of hemato-lymphatic interactions mediated by the interstitial space makes it possible to unite, within the module, processes of transmural, interstitial and axial (intervascular) transport. Movement of blood, interstitial fluid and lymph in tissues must be of oscillatory (discrete) character. As their trigger mechanism regulating rhythm and sequence of transport processes can serve the activity of metabolic lymphatic microvessels. Regulation of blood volume in capillaries depends on hydraulic and osmotic conditions in the interstitial space and on intensity of transmural transport. Topological approach can be effective in analyzing transport interrelations in tissues of different organs.