[Ultrastructural basis of acute cardiac insufficiency not associated with rhythm disorders]

On the basis of the data from the literature and own studies the genesis of acute cardiac insufficiency has been shown to be directly associated with a sharp decline in the effectiveness of intracellular energy transportation. A challenging factor in the transformation of the pathological process into acute cardiac insufficiency may consist in one of the three main types of influence: (1) hypoxia of the myocardium, (2) effects causing disorders in the calcium metabolism, and (3) additional mechanical loads on the already affected myocardium. The pattern of the observed ultrastructural changes may be used to a certain extent for the judgement on the type of effect which was most important in the genesis of acute cardiac insufficiency.