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Updated: Aug 11, 2025
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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
Published on: March 17, 2023
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Unraveling multilayered extracellular vesicles: Speculation on cause
Kelly Broad1,2, Sierra A Walker1, Irina Davidovich3
1Department of Biochemistry and Molecular Biology, Department of Physiology and Biomedical Engineering, Department of Transplantation, Mayo Clinic, Jacksonville, Florida, USA.
Journal of Extracellular Vesicles
|February 3, 2023
Summary
Multilayered extracellular vesicles (EVs) are increasingly recognized, yet their formation and functions remain unclear. Further research is crucial to understand these complex nanoparticles and their roles in cell communication.
Area of Science:
- Cell biology
- Nanotechnology
- Biochemistry
Background:
- Extracellular vesicles (EVs) are nanoparticles involved in intercellular communication.
- EVs are typically considered unilamellar but can also be multilamellar.
- The biogenesis and functions of multilamellar EVs are poorly understood.
Discussion:
- This commentary explores potential mechanisms behind multilamellar EV formation.
- It discusses the possible functional implications of EV layering.
- The heterogeneity of EVs, including their structural variations, is highlighted.
Key Insights:
- Multilamellar EVs represent a significant, understudied subpopulation.
- Understanding EV structure is key to deciphering their biological roles.
- There is a need to differentiate between unilamellar and multilamellar EV functions.
Outlook:
- Further investigation into multilamellar EV biogenesis is warranted.
- Comparative studies on unilamellar vs. multilamellar EVs are needed.
- This work calls for focused research to elucidate the complex nature of EVs.
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