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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Association Between Pre-Radiofrequency Catheter Ablation Serum Lipid Levels and Recurrence of Atrial Fibrillation in
Zhi-Zhao Li1,2, Ting Liu3, Qiong Huang4
1Department of Cardiology, Beijing DiTan Hospital, Capital Medical University, Beijing, China (mainland).
Insights
Recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation was observed in nearly 20% of patients. Pre-ablation serum lipid levels, specifically low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), were found to be significantly associated with AF recurrence in women.
Area of Science:
- Cardiology
- Electrophysiology
- Metabolic Syndrome
Background:
- Atrial fibrillation (AF) is a common arrhythmia often treated with radiofrequency catheter ablation.
- Understanding factors predicting recurrence after ablation is crucial for patient management.
- Lipid profiles are increasingly recognized as potential contributors to cardiovascular disease outcomes.
Purpose of the Study:
- To investigate the association between pre-ablation serum lipid levels and the risk of atrial fibrillation recurrence (RAF) after radiofrequency catheter ablation.
- To identify specific lipid parameters that may predict RAF in patients undergoing ablation.
Main Methods:
- A cohort of 412 patients with AF undergoing radiofrequency catheter ablation was studied.
- Fasting serum levels of triglycerides, HDL-C, LDL-C, and TC were measured pre-ablation.
- Patients were stratified into quartiles based on lipid levels; RAF was assessed using electrocardiography.
Main Results:
- Nearly 20% (19.90%) of patients experienced RAF post-ablation.
- Univariate analysis showed no significant association between LDL-C or TC and RAF.
- Multivariate analysis revealed that lower quartiles of TC and LDL-C were significantly associated with higher RAF in female patients.
Conclusions:
- Radiofrequency catheter ablation for AF has a recurrence rate of approximately 20%.
- Pre-ablation serum levels of LDL-C and TC are significantly associated with RAF, particularly in women.
- These findings suggest that lipid management may play a role in optimizing outcomes after AF ablation.
Abstract:
BACKGROUND This study from a single center in Beijing, China, included 412 patients with atrial fibrillation (AF) who underwent radiofrequency catheter ablation. We aimed to determine whether pre-ablation serum lipid levels were related to recurrence of atrial fibrillation (RAF). MATERIAL AND METHODS A total of 412 patients with AF who underwent radiofrequency catheter ablation were enrolled in the study. Fasting levels of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), were measured at baseline before ablation, and patients were classified according to lipid level quartiles (Q1-Q4). RAF was affirmed via 24-h electrocardiography or 12-lead electrocardiography. RESULTS A total of 82 (19.90%) patients experienced RAF. After adjusting for other relevant factors and sex, univariate logistic regression analysis revealed LDL-C (hazard ratio [HR], 1.17; 95% confidence interval [CI], 0.93-1.47) and TC (HR, 1.17; 95% CI, 0.96-1.42) levels were not significantly related to RAF. Multivariate logistic regression analysis revealed that, compared with the highest quartile (Q4), female patients with lower quartiles of TC had higher RAF, especially Q3 (HR, 16.24; 95% CI, 1.14-231.56). LDL-C levels were higher in Q1 than in Q4 but lower in Q2 and Q3 than in Q4 (Q1: HR, 1.34; 95% CI, 0.08-18.89; Q2: HR, 0.09, 95% CI, 0.06-1.52; Q3: HR, 0.02, 95% CI, 0.14-0.57). CONCLUSIONS This study showed RAF in almost 20% of treated patients and RAF was significantly related to pre-ablation serum levels of LDL-C and TC in women.
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