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Updated: Aug 11, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Heat Stroke Leading to a Fatal Outcome
Som N Chalise1, Ehsun Mirza1, Raza Malik2
1Pulmonary and Critical Care, Riverside Health System, Newport News, USA.
Abstract:
Heat stroke (HS) can cause several physiological changes in the body. In its most severe form, it can cause multi-organ failure including encephalopathy, circulatory shock, liver failure, renal failure, disseminated intravascular coagulation, and rhabdomyolysis among others. HS is a preventable condition; however, it can be life-threatening in severe forms. We present a case of HS in a 54-year-old male, with rapidly progressive multi-organ failure and a fatal outcome along with a brief literature review.
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