Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

4.7K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.7K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

34
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
34
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

122
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
122
Positron Emission Tomography01:29

Positron Emission Tomography

4.4K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.4K
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.5K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-Time SLAM-Based Correction and 3D Visualization for Fluorescence Lifetime Imaging.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same author

High-speed wide-field fluorescence lifetime imaging for intraoperative tumor visualization and in vivo multiplexing.

Biomedical optics express·2025
Same author

Optimized laser speckle-based imaging system and methods for deep tissue cerebral blood flow imaging in small rodents.

Neurophotonics·2025
Same author

Fluorescence Lifetime Imaging Enables In Vivo Quantification of PD-L1 Expression and Intertumoral Heterogeneity.

Cancer research·2024
Same author

Tunable dynamical tissue phantom for laser speckle imaging.

Biomedical optics express·2024
Same author

Laser speckle simulation tool based on stochastic differential equations for bio imaging applications.

Biomedical optics express·2023
Same journal

Generalizable framework for multi-site bone density prediction using non-dominant wrist optical biomarkers.

Biomedical optics express·2026
Same journal

Erratum: Review of dynamic optical coherence tomography for intracellular motility [Invited]: errata.

Biomedical optics express·2026
Same journal

Digital-micromirror-device-based illumination strategies for background suppression in single-molecule localization microscopy.

Biomedical optics express·2026
Same journal

Synergistic combination of convective self-assembly and hollow core fiber for sensitive SERS detection of glucose molecules.

Biomedical optics express·2026
Same journal

Multimodal diagnostic network integrating infrared and mass spectra for lung cancer.

Biomedical optics express·2026
Same journal

Multimodal Optical Biosensing for Precision Medicine and Healthcare: Introduction to the feature issue.

Biomedical optics express·2026
See all related articles

Related Experiment Video

Updated: Aug 11, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

12.5K

High-density diffuse correlation tomography with enhanced depth localization and minimal surface artefacts.

Ria Paul1, K Murali1, Hari M Varma1

  • 1Indian Institute of Technology Bombay (IITB), Mumbai-400076, India.

Biomedical Optics Express
|February 3, 2023
PubMed
Summary
This summary is machine-generated.

A new spatially weighted filter improves high-density diffuse correlation tomography (DCT) by reducing extracerebral noise and enhancing depth localization in blood flow imaging. This method was validated in simulations, phantoms, and human studies.

More Related Videos

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

14.2K
3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
07:01

3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography

Published on: October 24, 2019

9.9K

Related Experiment Videos

Last Updated: Aug 11, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

12.5K
Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

14.2K
3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
07:01

3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography

Published on: October 24, 2019

9.9K

Area of Science:

  • Biomedical optics
  • Medical imaging
  • Photonic technologies

Background:

  • Diffuse Correlation Tomography (DCT) is crucial for non-invasive blood flow imaging.
  • High-density DCT systems face challenges with extracerebral interferences and depth localization.
  • Existing methods may not adequately resolve superficial signal artifacts.

Purpose of the Study:

  • To introduce a novel spatially weighted filter for high-density DCT.
  • To improve the accuracy of blood flow imaging by reducing artifacts.
  • To enhance depth localization in reconstructed DCT images.

Main Methods:

  • A spatially weighted filter was applied to measurements and the Jacobian matrix.
  • High-density DCT was implemented using a modified Multi-speckle Diffuse Correlation Spectroscopy (M-DCS) system.
  • Iterative autocorrelation measurements at multiple delay-times were utilized for reconstruction.

Main Results:

  • The proposed filter effectively removed extracerebral interferences and artifacts.
  • Improved depth localization was achieved in reconstructed blood flow images.
  • Validation confirmed the scheme's efficacy in simulations, phantoms, and in-vivo studies.

Conclusions:

  • The spatially weighted filter is a promising technique for enhancing high-density DCT.
  • This method offers improved accuracy and depth resolution for blood flow imaging.
  • The findings support the clinical potential of advanced DCT techniques.