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Updated: Aug 11, 2025
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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
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Dopamine Receptors in Breast Cancer: Prevalence, Signaling, and Therapeutic Applications
Nira Ben-Jonathan1, Dana C Borcherding2, Eric R Hugo3
1Department of Cancer Biology, University of Cincinnati, Cincinnati, Ohio, USA.
Critical Reviews in Oncogenesis
|February 3, 2023
Summary
Dopamine type 1 receptors (D1R) are overexpressed in breast cancer (BC), promoting tumor growth. Targeting D1R with fenoldopam may offer a new therapeutic strategy for BC patients.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Breast cancer (BC) is a leading cause of cancer death in women, with limited options for advanced, resistant cases.
- Estrogen receptor and HER2 therapies improve outcomes but fail in a subset of patients, necessitating novel treatments.
Approach:
- This review examines the role of dopamine (DA) and its type 1 receptors (D1R) in BC pathogenesis and progression.
- Evidence suggests D1R overexpression in approximately 30% of BC cases correlates with advanced disease and poorer survival.
Key Points:
- D1R activation, signaling through the cGMP/PKG pathway, induces apoptosis, inhibits invasion, and enhances chemosensitivity in BC cells.
- Fenoldopam, a D1R agonist, suppressed D1R-expressing BC xenografts in mouse models.
- D1R may serve as a diagnostic/prognostic marker for BC.
Conclusions:
- Fenoldopam, an FDA-approved drug, shows potential for repurposing as a BC therapeutic agent for D1R-positive tumors.
- Modulators of the cGMP/PKG pathway could also be explored for BC treatment.
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