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Updated: Aug 11, 2025
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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
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Urinary Biomarkers and Overactive Bladder Symptoms Before and After Prolapse Surgery
Erin C Maetzold1, Donna A Santillan1, Kimberly A Kenne1
1From the Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics.
Urogynecology (Philadelphia, Pa.)
|February 3, 2023
Summary
This study found no significant link between preoperative urinary biomarkers and postoperative overactive bladder (OAB) symptoms in women undergoing pelvic organ prolapse (POP) surgery. Biomarker levels did not predict OAB symptom improvement after POP repair.
Area of Science:
- Urology
- Biomarkers
- Pelvic Floor Disorders
Background:
- Overactive bladder (OAB) is common in women with pelvic organ prolapse (POP).
- Limited research exists on urinary biomarkers for OAB in the context of POP.
Purpose of the Study:
- To investigate associations between preoperative urinary biomarkers and postoperative OAB symptoms in women undergoing POP surgery.
Main Methods:
- Prospective cohort study involving 77 women undergoing POP surgery.
- Preoperative and 3-month postoperative assessment of OAB symptoms using OAB-q SF and UDI-6.
- Measurement of urinary biomarkers for inflammation, neuroinflammation, and tissue remodeling.
Main Results:
- OAB symptoms significantly improved postoperatively.
- No significant correlations were found between preoperative urinary biomarkers and postoperative OAB symptom scores.
- No significant differences in biomarkers were observed between patients with and without OAB, or between pre- and postoperative samples in OAB patients.
Conclusions:
- Urinary biomarkers for tissue remodeling, inflammation, and neuroinflammation are not significantly correlated with OAB symptoms in women with POP.
- These biomarkers may not be useful for predicting OAB symptom outcomes after POP surgery.
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