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Targeted Small-Molecule Identification Using Heartcutting Liquid Chromatography-Infrared Ion Spectroscopy

Rianne E van Outersterp1, Jitse Oosterhout1, Christoph R Gebhardt2

  • 1Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7, 6525 ED Nijmegen, The Netherlands.

Analytical Chemistry
|February 3, 2023
PubMed
Summary

We developed a heartcutting liquid chromatography-infrared ion spectroscopy (LC-IRIS) method to overcome timescale differences. This automated setup successfully records multiple IR spectra for separated compounds, aiding molecular identification in complex samples.

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