A core outcome set for future research in ectopic pregnancy: an international consensus development study

Area of Science:

• Reproductive Health
• Clinical Trial Methodology
• Evidence-Based Medicine

Background:

• Methodological deficiencies exist in ectopic pregnancy (EP) research.
• Standardized outcome reporting is needed for reliable systematic reviews and randomized controlled trials.

Purpose of the Study:

• To develop a consensus-driven core outcome set for ectopic pregnancy (EP) research.
• To guide future clinical trials and systematic reviews in EP.

Main Methods:

• A comprehensive literature review and interviews identified potential outcomes.
• A 3-round Delphi survey involving 154 international participants (healthcare professionals, researchers, patients) was conducted.
• Consensus development meetings prioritized outcomes for the core set.

Main Results:

• Six outcomes achieved full consensus for the core outcome set.
• These include treatment success, resolution time, additional interventions, adverse events, mortality/severe morbidity, and treatment satisfaction.

Conclusions:

• The developed core outcome set provides a standardized framework for EP research.
• Implementation will enhance consistency in clinical trial reporting and patient-centered care.