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Updated: Aug 11, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
A pilot project of expert nurses for the follow-up of complex intravenous antimicrobial treatment
L Rolland1, A Mainguy1, S Boissier1
1Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France.
Objective:
To report a pilot project of expert nurses for outpatient parenteral antimicrobial treatment (OPAT) follow-up.
Methods:
Three nurses with specific training on antibiotics started a state-funded programme including: i) consultations for OPAT follow-up; ii) hotline for satellite hospitals; iii) peer training. Patients' data were prospectively collected. A representative sample of patients and physicians was interviewed to learn about their opinion on the project.
Results:
From December 2020 to December 2021, 118 patients (median age 66.5 years [52-75], male-to-female ratio 2.5) were enrolled, for a total of 621 consultations. Patients were mostly on OPAT for bone and joint infections (n = 76, 64 %) and cardiovascular infections (n = 16, 14 %), for a median duration of 29 days [22-57]. Eleven patients (9 %) required unplanned hospital admissions, and three experienced treatment failure. Most patients (21/22) and physicians in charge (10/10) reported a high level of satisfaction.
Conclusions:
Nurses may be important actors for OPAT follow-up.
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