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Related Concept Videos

Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

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The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
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Metabolic States of the Body: The Absorptive State01:25

Metabolic States of the Body: The Absorptive State

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During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
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Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

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Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
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Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

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Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
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Related Experiment Video

Updated: Aug 11, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Fasting: From Physiology to Pathology.

Dongmei Tang1, Qiuyan Tang2, Wei Huang3

  • 1Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, 610041, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 4, 2023
PubMed
Summary
This summary is machine-generated.

Fasting combats overnutrition, a risk factor for diseases like cancer and neurodegeneration. This review highlights fasting

Keywords:
agingdiseasesfasting-mimicking dietintermittent fastingtime-restricted feeding

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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
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Related Experiment Videos

Last Updated: Aug 11, 2025

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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
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Area of Science:

  • Nutritional Science
  • Molecular Biology
  • Gerontology

Background:

  • Overnutrition is a significant risk factor for prevalent human diseases.
  • Fasting, an ancient practice, is increasingly recognized for its health benefits.
  • Recent research reveals fasting's impact on the molecular clock, gut microbiome, and tissue homeostasis.

Purpose of the Study:

  • To review recent studies on fasting's role in physiology and pathology.
  • To highlight the therapeutic potential of fasting in disease prevention and treatment.
  • To explore combining pharmacological interventions with fasting for novel treatment regimens.

Main Methods:

  • Comprehensive review of recent animal and human studies.
  • Analysis of molecular and physiological mechanisms underlying fasting's effects.
  • Synthesis of current research on fasting's therapeutic applications.

Main Results:

  • Fasting can slow aging and protect against neurodegenerative diseases, metabolic disorders, and cancers.
  • Fasting influences the molecular clock, gut microbiome, and tissue homeostasis.
  • Fasting offers a potential strategy to delay aging and treat diseases with minimal side effects.

Conclusions:

  • Fasting is a promising dietary intervention for combating overnutrition and associated diseases.
  • Understanding fasting's mechanisms can lead to new therapeutic strategies.
  • Combining fasting with pharmacological treatments may offer enhanced disease management.