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Biochemical Measurement of Neonatal Hypoxia
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Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

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Carboxyhemoglobin as biomarker of prematurity complications

Carlo Dani1, Giulia Remaschi2, Nicolò Monti2

  • 1Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy; Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 4, 2023
PubMed

Insights

Elevated carboxyhemoglobin (COHb) levels in the first week of life predict the risk of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH) in preterm infants. This biomarker aids in early identification of infants susceptible to oxidative stress complications.

Area of Science:

  • Neonatal Medicine
  • Biomarkers
  • Oxidative Stress

Background:

  • Carboxyhemoglobin (COHb) is a biomarker for oxidative stress.
  • Previous studies suggest a link between COHb levels and prematurity complications.

Purpose of the Study:

  • To assess the correlation between COHb levels and the risk of bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and retinopathy of prematurity (ROP).

Main Methods:

  • Retrospective study of 178 preterm infants (gestational age 27.0 ± 1.5 weeks).
  • Recorded COHb levels during the first seven days of life.
  • Analyzed data for associations with BPD, IVH, and ROP.

Main Results:

  • Higher COHb on day 7 increased risk for moderate-to-severe BPD (OR 4.552).
  • Higher COHb on day 4 increased risk for grade 2-4 IVH (OR 5.537).
  • No significant correlation found between COHb and ROP risk.

Conclusions:

  • COHb measured in the first week of life predicts BPD and IVH risk in very preterm infants.
  • COHb assessment is clinically useful for early identification of high-risk infants.
  • COHb is not a predictor for ROP in this cohort.
Abstract

Keywords:
Bronchopulmonary dysplasiaCarboxyhemoglobinIntraventricular haemorrhagePreterm infantRetinopathy of prematurity

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