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Carotid Intima-media Thickness in Hemodialysis Patients and Related Biochemical and Clinical Factors

Azita Zafar Mohtashami, Babak Hadian1, Mohammad Heidarian

  • 1Department of Internal Medicine, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Lorestan, Iran. nazbani@yahoo.com.

Iranian Journal of Kidney Diseases
|February 5, 2023
PubMed

Insights

In hemodialysis patients, increased carotid artery intima-media thickness (CIMT) is common. Age and serum magnesium levels are significantly associated with CIMT, suggesting their importance in cardiovascular risk assessment.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Cardiovascular complications are a leading cause of mortality in chronic kidney disease (CKD).
  • Carotid artery intima-media thickness (CIMT) is recognized as a predictor of cardiovascular disease (CVD).
  • Uremic and general risk factors contribute to CVD in CKD patients.

Purpose of the Study:

  • To investigate the association between carotid artery intima-media thickness (CIMT) and various clinical and biochemical factors in hemodialysis patients.
  • To identify predictors of increased CIMT in this high-risk population.

Main Methods:

  • An analytical cross-sectional study involving 128 hemodialysis patients.
  • Data collection included medical records review, patient interviews, serum analysis, carotid artery Doppler ultrasound, and questionnaires.
  • Statistical analyses comprised descriptive statistics, bivariate correlation, and general linear model (GLM).

Main Results:

  • A significant percentage of hemodialysis patients exhibited increased CIMT.
  • Bivariate analysis revealed significant relationships between CIMT and age, serum albumin, serum magnesium, hypertension, and history of CVD.
  • GLM analysis confirmed a statistically significant association between CIMT, age, and serum magnesium concentration.

Conclusions:

  • Increased CIMT is prevalent in hemodialysis patients.
  • Age and serum magnesium are significant predictors of CIMT in this cohort.
  • Further longitudinal studies and multivariate analyses are recommended to elucidate risk factors and guide preventive strategies.
Abstract

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