Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Study on the causal relationship between serum albumin and carpal tunnel syndrome and the mediating role of leptin].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026

Same author

[Multivariate analysis and construction and validation of a nomogram model from data of 1610 patients with non-tumor-related anastomotic stenosis after rectal cancer surgery].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2024

Same author

[A comparative study of the curative effects between butterfly-shaped flap and propeller flap based on the dorsal branch of digital artery in repairing the wound in volar aspect of finger].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2023

Same author

On the use of Monkhorst-Pack scheme to evaluate superconductivity and the issue of umklapp electron-phonon interactions.

Physical chemistry chemical physics : PCCP·2023

Same author

[Epidemiological characteristics and influencing factors of <i>Blastocystis hominis</i> infection among children with diarrhea under five years of age in Guangzhou City].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2023

Same author

[Effects of bariatric surgery on sex hormones in male patients with obesity].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2022

Same journal

[Role of gut-derived immune cells and the gut-lung axis in acute respiratory distress syndrome].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

Same journal

[Pathophysiological mechanisms and clinical management of neurological complications associated with acute respiratory distress syndrome].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

Same journal

[Research progress on miRNA-regulated macrophage polarization and autophagy in immune escape by <i>Mycobacterium tuberculosis</i>].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

Same journal

[Research advances in the impact of nitroimidazole-containing regimens on the QT interval during the treatment of drug-resistant tuberculosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

Same journal

[Mechanisms and progress of airway mucus retention in bronchial asthma].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

Same journal

[Acute lung injury caused by sevoflurane: a case report].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 11, 2025

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

[Angiogenesis and pulmonary fibrosis].

Y Wu¹, J Zhang², J X Zheng¹

¹Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China.

Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases

|February 5, 2023

Summary

This summary is machine-generated.

Idiopathic pulmonary fibrosis (IPF) involves lung damage and fibrotic repair. This review explores how new blood vessel formation (angiogenesis) contributes to IPF development and suggests potential therapeutic targets.

More Related Videos

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Related Experiment Videos

Last Updated: Aug 11, 2025

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Area of Science:

Pulmonary Medicine
Pathology
Vascular Biology

Background:

Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible lung disease.
Its pathogenesis is not fully understood, but microvascular remodeling is implicated.
Angiogenesis may play a role in initiating IPF.

Conclusions:

Angiogenesis is a significant factor in the development of idiopathic pulmonary fibrosis.
Further research into angiogenesis pathways may lead to novel IPF treatments.
Targeting angiogenesis offers a potential therapeutic strategy for IPF.