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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
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Risk factors for diabetic foot ulcers: A systematic review and meta-analysis
W H Tang1, Y N Zhao2, Z X Cheng2
1First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, China.
Vascular
|February 6, 2023
Summary
Advanced age, male sex, obesity, and long-term diabetes are key risk factors for diabetic foot ulcers (DFU). Early intervention is crucial for preventing DFU development in at-risk patients.
Area of Science:
- Diabetology and Vascular Medicine
- Public Health and Epidemiology
Background:
- Diabetic foot ulcers (DFU) represent a significant complication of diabetes mellitus, leading to substantial morbidity and healthcare costs.
- Identifying and understanding the multifactorial risk landscape for DFU is critical for effective prevention strategies.
Approach:
- A comprehensive systematic review and meta-analysis was conducted, synthesizing data from 26 diverse studies (3 cohort, 22 case-control, 1 cross-sectional).
- Searches were performed across major databases (Cochrane Library, PubMed, Web of Science, SinoMed, CNKI, VIP, Wanfang Data) up to March 2022.
Key Points:
- Significant risk factors identified include advanced age, male gender, elevated BMI, prolonged diabetes duration, and presence of diabetic complications (nephropathy, neuropathy, retinopathy).
- Biometric indicators such as elevated systolic blood pressure, fasting glucose, glycated hemoglobin, triglycerides, fibrinogen, white blood cell count, and C-reactive protein were associated with increased DFU risk.
- Conversely, decreased ankle-brachial index and total protein levels were risk factors, while increased HDL cholesterol showed a protective effect.
Conclusions:
- The study confirms a wide array of risk factors contributing to DFU development.
- Emphasizes the necessity for early and proactive risk assessment and intervention in patients with diabetes to mitigate the incidence of foot ulcers.
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