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Updated: Aug 11, 2025
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Purification and Expansion of Mouse Invariant Natural Killer T Cells for in vitro and in vivo Studies
Published on: February 15, 2021
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CD8+ T-cell immunity orchestrated by iNKT cells
Yingyu Qin1, Xueyang Bao1, Mingzhu Zheng1
1Department of Pathogenic Biology and Immunology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Frontiers in Immunology
|February 6, 2023
Summary
Invariant natural killer T (iNKT) cells enhance CD8+ T cell immunity against infections and cancers. This review explores iNKT cell roles in adaptive immunity, memory formation, and aging effects on T cell responses.
Area of Science:
- Immunology
- Cellular Biology
- Cancer Research
Background:
- CD8+ T cells are crucial for adaptive immunity against viral infections and cancers.
- CD8+ T cell immunotherapy shows promise in treating hematologic malignancies.
- Innate immune cells, like invariant natural killer T (iNKT) cells, are vital for effective adaptive immunity.
Purpose of the Study:
- To review the contribution of iNKT cells to CD8+ T cell immunity.
- To discuss iNKT cell-mediated cross-priming and memory formation.
- To explore advancements in understanding memory CD8+ T cell differentiation and aging-related impairments.
Main Methods:
- Literature review of studies on iNKT cells and CD8+ T cell immunity.
- Analysis of mechanisms in memory CD8+ T cell differentiation.
- Examination of the impact of aging on T cell immunity.
Main Results:
- iNKT cells significantly modulate innate and adaptive immune responses through cytokine secretion.
- iNKT cells play a role in anti-cancer and anti-viral defenses, similar to CD8+ T cells.
- Recent research sheds light on memory CD8+ T cell development and age-associated decline.
Conclusions:
- iNKT cells are key modulators of CD8+ T cell immunity, impacting cross-priming and memory.
- Understanding iNKT cell functions is crucial for developing effective immunotherapies.
- Aging impairs T cell immunity, highlighting the need for further research into T cell rejuvenation.
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