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Long-term bidirectional association between asthma and attention deficit hyperactivity disorder: A big data cohort
Hye Jin Park1, Young Hyeon Kim1, Da Ye Na1
1Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
This study found that individuals with asthma have a higher incidence of attention deficit hyperactivity disorder (ADHD), and vice versa. These findings confirm a bidirectional relationship between childhood asthma and ADHD, emphasizing the need for careful management of both conditions.
Area of Science:
- Epidemiology
- Pediatrics
- Psychiatry
Background:
- Previous research suggested a link between attention deficit hyperactivity disorder (ADHD) and asthma.
- However, robust evidence to confirm this association was lacking.
Purpose of the Study:
- To investigate the bidirectional relationship between asthma and ADHD.
- Utilized a 12-year big data cohort study for comprehensive analysis.
Main Methods:
- A cohort of 3.5 million individuals was randomly sampled from the National Health Insurance Service (NHIS).
- Study 1 assessed ADHD incidence in relation to asthma.
- Study 2 analyzed asthma incidence in relation to ADHD, employing propensity score matching for control group selection.
Main Results:
- Individuals with asthma showed a 1.17 times higher adjusted hazard ratio (aHR) for ADHD.
- ADHD was associated with a 1.10 times higher aHR for asthma.
- Significant associations were observed in various subgroups, particularly in younger children with ADHD and asthma.
Conclusions:
- A bidirectional relationship exists between asthma and ADHD.
- Rigorous management of childhood asthma and ADHD is crucial.
- Findings highlight the importance of considering comorbid conditions in clinical practice.
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