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Related Experiment Video

Updated: Aug 11, 2025

Determining Bile Duct Density in the Mouse Liver

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

Distinction between Mitochondrial Antibody-Positive and -Negative Primary Biliary Cholangitis.

Venkata Vinod Kumar Matli¹, David F Dies², Sudha Pandit³

¹Department of Internal Medicine, Christus Highland Medical Center, Shreveport, LA, USA.

Case Reports in Gastroenterology

|February 6, 2023

Summary

Antimitochondrial antibody-negative primary biliary cholangitis (AMA-neg PBC) is a variant of AMA-positive PBC. Recognizing and differentiating AMA-neg PBC is crucial for diagnosis and management, even with similar treatment outcomes.

Area of Science:

Hepatology
Autoimmune Disorders
Immunology

Background:

Primary biliary cholangitis (PBC) is an autoimmune liver disease.

Keywords:

AMA-negative PBC AMA-positive PBC Antimitochondrial antibody Autoimmune cholangitis Overlap syndrome Primary biliary cholangitis

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Antimitochondrial antibody-positive PBC (AMA-pos PBC) is the common form.

Antimitochondrial antibody-negative PBC (AMA-neg PBC) is a less common variant.