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Updated: Aug 11, 2025
09:52
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
9.5K
Ototoxicity of Artemisinin-Based Combination Therapy: A Case Presentation
Ripu Daman Arora1, Monalisa Jati1, Nitin M Nagarkar1
1Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Raipur, Chhattisgarh 492099 India.
Summary
Neuroauditory-toxicity is a concern in severe malaria treatment. This report highlights the potential hearing loss associated with artemisinin-based combination therapy, emphasizing the need for auditory monitoring.
Area of Science:
- Pharmacology
- Neurology
- Otolaryngology
Background:
- Severe malaria treatment necessitates careful consideration of potential side effects.
- Neuroauditory-toxicity is a critical, yet often underestimated, concern in managing severe neurological conditions.
- Artemisinin-based combination therapy (ACT) is the standard for cerebral malaria, but its ototoxic potential requires investigation.
Purpose of the Study:
- To investigate the ototoxic effects of artemisinin, a key component in ACT for cerebral malaria.
- To underscore the importance of auditory monitoring during the treatment of severe malaria.
Main Methods:
- This report is based on clinical observations and existing literature regarding artemisinin's effects.
- Analysis of patient outcomes and reported auditory adverse events associated with ACT.
Main Results:
- Artemisinin, while effective against malaria, may contribute to hearing loss.
- The attribution of hearing loss to artemisinin in cerebral malaria treatment remains an area needing further clarification.
Conclusions:
- Auditory monitoring should be an integral part of managing patients with severe malaria treated with ACT.
- Clinicians must remain vigilant for potential neuroauditory-toxicity when prescribing artemisinin-based therapies.
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