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Construction of the ceRNA network in the progression of acute myocardial infarction

Hui Liu1, Shuai Qin1, Yuanyuan Zhao1

  • 1Department of Cardiovascular Surgery, Linfen Central Hospital Linfen, Shanxi, China.

American Journal of Cardiovascular Disease
|February 6, 2023
PubMed

Insights

This study reveals a circRNA-miRNA-mRNA network crucial for acute myocardial infarction (AMI) progression, identifying key immune-related genes and circRNAs that could inform new therapeutic strategies for this widespread cardiovascular disease.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Genomics

Background:

  • Acute myocardial infarction (AMI) presents a significant global health burden.
  • Noncoding RNAs, including circRNAs, lncRNAs, and miRNAs, are implicated in cardiovascular disease pathogenesis.
  • The specific circRNA-miRNA-mRNA regulatory network in AMI requires further elucidation.

Purpose of the Study:

  • To investigate the circRNA-miRNA-mRNA network involved in the occurrence and development of AMI.
  • To identify key regulatory molecules and pathways contributing to AMI pathology.
  • To provide insights for potential therapeutic strategies for AMI.

Main Methods:

  • Downloaded and analyzed circRNA, miRNA, and mRNA expression datasets for AMI from the GEO database.
  • Utilized RStudio for differential expression analysis and Gene Ontology (GO) and KEGG pathway enrichment.
  • Employed Protein-Protein Interaction (PPI) networks and Cytoscape for hub gene identification and constructed the ceRNA network using starbase and circinteractome databases.

Main Results:

  • Identified 46 differentially expressed mRNAs, 65 miRNAs, and five circRNAs associated with AMI.
  • GO and KEGG analyses highlighted immune response pathways, including IL-17, Toll-like receptor, TNF, chemokine, and NF-kappaB signaling.
  • Discovered 10 hub genes (e.g., TLR2, IL1B, CCL4, CCL20) and identified circRNA_023461 and circRNA_400027 as key regulators in the circRNA-miRNA-mRNA network.

Conclusions:

  • Uncovered a novel circRNA-miRNA-mRNA regulatory network in AMI.
  • Demonstrated the involvement of immune-related genes and pathways in AMI progression.
  • Highlighted circRNA_023461 and circRNA_400027 as potential therapeutic targets for improving AMI treatment strategies.

Keywords:
acute myocardial infarctionceRNA networkcircRNA-miRNA-mRNA

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