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Circadian rhythms in auditory hallucinations and psychosis
Hong-Viet V Ngo1,2, Henrik Oster2,3, Christina Andreou2,4
1Department of Psychology, University of Lübeck, Lübeck, Germany.
Acta Physiologica (Oxford, England)
|February 6, 2023
Summary
Disruptions in the body's internal clock (circadian rhythms) may contribute to auditory hallucinations in psychosis. Targeting these rhythms could offer new treatments for psychotic disorders.
Area of Science:
- Neuroscience
- Chronobiology
- Psychiatry
Background:
- Circadian rhythms govern physiological and behavioral adaptations to the 24-hour day-night cycle.
- Disruptions in circadian clock function are increasingly implicated in various human ailments.
- This review specifically examines the link between circadian dysregulation and psychosis, focusing on auditory hallucinations.
Approach:
- Review of recent empirical evidence and conceptual advances.
- Focus on the role of circadian disruption in auditory hallucinations.
- Exploration of underlying physiological mechanisms, including cortical network imbalances and dopaminergic signaling.
Key Points:
- Circadian disruption is a potential contributing factor to auditory hallucinations in psychosis.
- A central mechanism involves a dysbalance between excitation and inhibition in cortical networks.
- This imbalance leads to disinhibition of dopaminergic signaling, further impacting psychosis symptoms.
Conclusions:
- Circadian dysregulation represents a significant area of investigation for understanding psychosis.
- Two potential avenues for experimental intervention targeting circadian influences are proposed.
- Modulating circadian rhythms may offer novel therapeutic strategies for alleviating hallucinations in psychotic disorders.
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